Statistical Framework for in Vivo Drug Combination Studies

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Documentation for package ‘SynergyLMM’ version 1.1.0

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APrioriPwr _A Priori_ Synergy Power Analysis Based on Variability and Drug Effect
CookDistance Cook's distance for individual subjects
getRTV Helper function to calculate the relative tumor volume from an imput data frame of tumor growth
grwth_data Example Tumor Growth Data
lmmModel Linear Mixed Effect Model for Tumor Growth
lmmModel_estimates Get estimates from a linear mixed model of tumor growth data
lmmModel_estimates.explme Get estimates from a linear mixed model of tumor growth data
lmmModel_estimates.gompertzlme Get estimates from a linear mixed model of tumor growth data
lmmSynergy Synergy calculation using linear-mixed and non-linear mixed-effect models
lmmSynergy.explme Synergy calculation using linear-mixed and non-linear mixed-effect models
lmmSynergy.gompertzlme Synergy calculation using linear-mixed and non-linear mixed-effect models
logLikSubjectDisplacements Likelihood displacements for the model
ObsvsPred Observed vs predicted values and performance of the model
plot_lmmModel Plotting of tumor growth data from a fitted model
plot_lmmSynergy Plotting synergy results
plot_ObsvsPred Plots of Observed vs Predicted Values
plot_ranefDiagnostics Plots for random effects diagnostics
plot_residDiagnostics Plots for residuals diagnostics
plot_SynergyLMM Plotting SynergyLMM results
PostHocPwr Post hoc power calculation based on simulations of the synergy evaluation using LMM.
Pwr Calculates power based on a model fit
Pwr.lme Performs power calculations
PwrSampleSize _A Priori_ Synergy Power Analysis Based on Sample Size
PwrTime _A Priori_ Synergy Power Analysis Based on Time
ranefDiagnostics Diagnostics of random effects of the linear mixed model
residDiagnostics Diagnostics of residuals of the linear mixed model
simulateTumorGrowth Helper function to simulate tumor growth data for a two-drug combination experiment.